In 1988, she had her first professional acting role in the television film The Night Train to Kathmandu, and later that year, she appeared in her first feature film, Two Moon Junction. Following more small television appearances such as the “Fair Exchange” (1989) and a 1989 role as a French girl (she was 14 at the time) on a Married… with Children episode and film roles, she gained notoriety with the romance film Return to the Blue Lagoon (1991).
In 1992, she also appeared in “Kuffs” as Christian Slater’s love interest. She appeared in 1993’s Dazed and Confused, before a short hiatus. Jovovich then acted alongside Bruce Willis in the science fiction film The Fifth Element (1997), and later played the title role in The Messenger: The Story of Joan of Arc (1999). In 2002, she starred in the video game adaptation Resident Evil, which spawned four sequels: Resident Evil: Apocalypse (2004), Resident Evil: Extinction (2007), Resident Evil: Afterlife (2010) and Resident Evil: Retribution (2012).